Inflammation Research Association Announces
Interactive Job Board Focused on Immunology and Inflammation Opportunities
Our client is a clinical-stage company, with 6 compounds (3 antibodies and 3 small molecules) being evaluated across multiple clinical trials in oncology and IO. With a robust pipeline of preclinical and discovery programs that will continue to fuel the development pipeline, and at least another antibody and 1-2 small molecules expected to enter the clinic in 2022 this is an exciting time to join. The recent expansion of the multi-year collaboration will greatly accelerate our development activities in the inflammation space, creating a unique professional opportunity for experienced individuals.
- Leadership role within the Biology group and a key representative of the Biology function, with significant interactions across all of research (Bioinformatics, Chemistry, Translational Science and Quantitative Biology).
- Recruit and build a team of bench level personnel (Ph.D. and BS/MS levels)
- Working with Research team members to design and implement strategy, spanning the various stages of drug discovery, with the goal of advancing new molecules into first in human trials including:
- target identification & validation
- elucidating the mechanism of action for drug candidates
- experience with both in vitro and in vivo inflammatory models
- prioritization of indications, with experimental validation
- significant contributions to early development through the identification of patient selection and biomarker criteria
- Oversight of group members on both technical and strategic levels to meet program goals
- Mentorship of both non-PhD and PhD level staff
- Implementation of new technologies/innovations to support drug discovery
- Oversight of technical reports and non-clinical sections to support regulatory filings
- Working with Research Leadership to set project objectives
- Responsibility for both small molecule and antibody programs
- Represent programs with both to the broader scientific community and strategic collaboration partners
- D. degree in Immunology, Pharmacology, Biology or related discipline
- In depth Immunology experience
- 6+ years of relevant experience in a high-quality industry environment
- Detailed understanding of the many elements involved in a successful drug discovery program exemplified by having successfully shepherded drug candidates, antibody and/or small molecule, from the discovery/validation phase, through active drug discovery and on to regulatory filing
- Experience working with Translational science to develop target engagement, biomarker, and patient selection criteria
- Outstanding verbal and presentational skills with the expectation of representing Arcus effectively to collaborators and industry leaders
- A high level of proficiency in scientific writing with frequent presentation of novel world-class science to external audiences is an important component of our business strategy including conference abstracts, posters, manuscripts, and research reports to support regulatory filings
- Proven ability to oversee and manage complex interactions with external organizations in addition to CROs, such as corporate collaborations and other external partnerships.
- Demonstrated excellence in identifying human talent, hiring, developing, mentoring, and managing high-performing groups. Technical depth and excellence are table stakes for this role.
Pareto Bio – Research Associate
Location: Cambridge, Massachusetts
At Pareto we are pioneering a mechanism-driven approach to rationally design microbiota-informed therapies against highly prevalent clinical diseases. By targeting the gut microbiota, we seek to redirect dysregulated immune pathways and restore balance. Our microbial therapies are engineered to promote targeted immunomodulation and enhance gut barrier functions while demonstrating sustained and durable effects. We are seeking a full-time research associate to drive cutting-edge research to deliver meaningful therapies to patients.
Job responsibilities – the research associate will undertake the following analyses:
- Molecular biology: PCR, qPCR, gel electrophoresis, antibody and antigen ELISAs
- Microbiology: grow bacteria using aseptic technique and under anaerobic conditions, isolate strains from human and animal samples, establish cell banks. Prepare and optimize growth media and supporting reagents
- Review scientific literature to establish and/or optimize experimental protocols
- Maintain organized documentation of work performed
- Present scientific data to team
- Oversee a safe, clean, and well-organized laboratory and maintain laboratory equipment
- Establish relationships with vendors for maintaining supply inventories
- B.S. in biology, chemistry or a quantitative science
- >1 year experience working in a microbiology laboratory setting
- Familiarity/experience with molecular biology and microbiology techniques
- Familiarity/experience using common tools for nucleic acid analyses including BLAST and primer development tools
- Excellent critical thinking and quantitative skills with good attention to detail
- Excellent oral and written communication skills
- Ability to work independently as well as within a strong collaborative team
- Strong interest in utilizing the gut microbiome to treat and prevent disease
To apply, please submit a cover letter responsive to this posting with your CV and 3 references to email@example.com. For candidates within 2 years of completing an undergraduate degree, please also include a copy of your undergraduate transcript.