Inflammation Research Association Announces
Interactive Job Board Focused on Immunology and Inflammation Opportuniies


Jansen Research & Development – Senior Scientific Director, Discovery – IL-23 PAS

https://jobs.jnj.com/jobs/4083190114?lang=en-us

Job Description
Requisition ID: 4083190114

Janssen Research & Development, LLC is recruiting for a Senior Scientific Director of discovery for the IL-23 Pathway Area Stronghold (PAS), located in Spring House, PA or La Jolla, CA.

Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.JanssenRnD.com for more information.

We are seeking a Senior Scientific Director to provide oversight of a group within the Immunology therapeutic area with a focus on driving novel biology and innovative approaches in drug discovery to accelerate delivery of therapeutic solutions for patients with IL-23 pathway driven diseases with high unmet need.

Reporting directly to the Vice President Immunology Discovery and working in close collaboration with the IL-23 Pathway Area Stronghold (PAS), the successful candidate will be responsible for refining and implementing our discovery strategy to identify IL-23 pathway driven diseases and prosecute novel therapeutic approaches.

The successful candidate will also be responsible for aggressively establishing collaborations with world-class academic and clinical thought leaders in this area to access state of the art expertise and technologies that drive innovative approaches to drug discovery. Ultimately these efforts will provide new insights into diseases which are meditated by IL-23 as well as novel therapeutic solutions. In addition, the successful candidate will be expected to identify and evaluate novel therapeutic platforms and delivery strategies that have the potential to lead to transformational treatments.

The successful candidate will work within a strong matrixed environment with colleagues within the Immunology therapeutic area, the IL-23 PAS and other functional areas including our Innovation Centers to explore both internal and external opportunities. They will participate on the Discovery Senior leadership team to enable to the Discovery function to execute on its overall strategy and will manage a scientific group and lead teams. They will lead efforts into disease understanding at the molecular level and partner with technology platform organizations to develop New Molecular Entities.

Qualifications
Requirements:

  • The successful candidate will have a PhD in Pharmacology/Biochemistry/Immunology or related field.
  • Minimum of 12 years’ experience in the field of Immunology. Understanding of IL-23 biology in multiple cell types, tissues and diseases is key.
  • The successful candidate will have previous line management experience and will have a proven track record of success in the Immunology field through publications and presentations.
  • Previous Industry experience and knowledge of small molecule based Drug Discovery is preferred.
  • Strong communications skills are critical as is a proven ability to work in a matrix environment while establishing and maintaining effective internal and external collaborations.

Primary Location
United States-Pennsylvania-Spring House-
Organization
Janssen Research & Development, LLC. (6084)
Job Function
R&D
Requisition ID
4083190114


Jansen Research & Development – Senior Scientific Director, Gastroenterology DAS

https://jobs.jnj.com/jobs/3831190110?lang=en-us

Job Description
Requisition ID: 3831190110

Janssen Research & Development, LLC is recruiting for a Senior Scientific Director of discovery for the Gastroenterology Disease Area Stronghold (DAS), located in Spring House, PA or La Jolla, CA

Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.JanssenRnD.com for more information.

We are seeking a Senior Scientific Director to provide oversight of a group within the Immunology therapeutic area with a focus on driving innovative new approaches in drug discovery to address unmet needs in gastroenterology.

Reporting directly to the Vice President Immunology Discovery and working in close collaboration with the Gastroenterology Disease Area Stronghold, the successful candidate will be responsible for refining and implementing our discovery strategy to identify and prosecute novel therapeutic approaches to target key pathogenic and/or regulatory pathways underlying GI diseases including Crohn’s and Ulcerative Colitis.

The successful candidate will also be responsible for aggressively establishing collaborations with world-class academic and clinical thought leaders in this area to access state of the art expertise and technologies that drive innovative approaches to drug discovery. Ultimately these efforts will provide new insights into targeting key mechanisms involved in triggering and perpetuating disease. In addition, the successful candidate will be expected to identify and evaluate novel therapeutic platforms and delivery strategies that have the potential to lead to transformational treatments.

The successful candidate will work within a strong matrixed environment with colleagues within the Immunology therapeutic area, the Gastroenterology DAS and other functional areas including our Innovation Centers to explore both internal and external opportunities. They will participate on the Discovery Senior leadership team to enable to the Discovery function to execute on its overall strategy and will manage a scientific group and lead teams. They will lead efforts into disease understanding at the molecular level and partner with technology platform organizations to develop New Molecular Entities.

Qualifications
Requirements:

  • The successful candidate will have a PhD in Pharmacology/Biochemistry/Immunology or related field.
  • A minimum of 12 years’ experience in the field of Immunology.
  • Understanding key pathways and mechanisms within inflammatory and tissue resident cells, including host/ microbiome interface that may underlie disease processes in gastroenterology is key.
  • The successful candidate will have previous line management experience and will have a proven track record of success in the Immunology field through publications and presentations.
  • Previous Industry experience and knowledge of small molecule and/or biologic based Drug Discovery is essential.
  • Strong communications skills are critical as is a proven ability to work in a matrix environment while establishing and maintaining effective internal and external collaborations.

Primary Location
United States-Pennsylvania-Spring House-
Organization
Janssen Research & Development, LLC. (6084)
Job Function
R&D
Requisition ID
3831190110


Pfizer – Postdoctoral Fellow, Inflammation and Immunology – Focus on Interaction of the Microbiome in Inflammatory Bowel Disease

Location: Cambridge, MA

ROLE SUMMARY
The microbiome has emerged as a key contributor to autoimmune and inflammatory disorders, including the pathogenesis of Inflammatory Bowel Diseases (IBD). The Epithelial Biology and Systems Immunology Groups within Pfizer’s Inflammation and Immunology Research Unit are actively examining host-microbiome interactions in IBD. We are seeking a highly motivated, talented, and creative postdoctoral candidate with a strong background in microbiology, molecular biology, microbial immunology or a related field, and familiarity with bioinformatic and/or statistical methods to investigate the role of host-microbiome interactions in health and disease in preclinical IBD models. The candidate will be responsible for running in vivo studies to examine how perturbations to the microbiome and host immune system affect disease outcomes, and use novel computational approaches to analyze and integrate multi-type omics datasets.

ROLE RESPONSIBILITIES

  • Collaborate closely with experimental and computational scientists to explore fundamental research questions with an emphasis on novel discoveries that will result in high impact publications.
  • Participate in design of targeted in vivo interventions to address key questions about the role of the microbiome in treatment efficacy and disease outcomes in preclinical IBD models.
  • Study the host and microbiome dynamics by applying discovery-based computational approaches to multi-type omics data.
  • Develop and utilize cell-based systems to functionally validate in vivo observations.
  • Organize, interpret, and analyze data, and identify areas where key knowledge is lacking.
  • Effectively communicate data and results at internal and external meetings/conferences.

BASIC QUALIFICATIONS

  • Recent Ph.D. in biology, microbiology, molecular biology, cell biology, or a related field.
  • Experience running in vivo disease models, including harvesting, processing, and analyzing tissue.
  • Experience with bacterial and mammalian cell/tissue culture and related techniques, including ELISA, qPCR, western blot, and/or fluorescence microscopy.
  • Excellent communication and organizational skills, and willingness to learn new skills.
  • Demonstrated research productivity by first-author publications in peer-reviewed journals.

PREFERRED QUALIFICATIONS

  • Familiarity with computational tools for analyzing genetic and genomic data.
  • Experience culturing aerobic and anaerobic bacteria, and running bacterial infection models in the gastrointestinal system.

EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.   Pfizer is an E-Verify employer.

Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Apply
Apply with LinkedIn


Pfizer – Postdoctoral Fellow, Inflammation and Immunology – Target Discovery for Rheumatoid Arthritis With a Focus on Synovial Fibroblasts

Location: Cambridge, MA

ROLE SUMMARY
At Pfizer, we strive to improve the life of patients through innovative therapy. Our work in the discovery group within the Inflammation & Immunology research unit is to build the foundation of tomorrow’s medicine by deciphering disease pathways in autoimmunity to identify novel therapeutic targets.

We are looking for a highly motivated scientist to join our group as a postdoctoral fellow. Your research will focus on identifying and characterizing the role of synovial fibroblast subsets in rheumatoid arthritis. Deepening our understanding of the protective and pathogenic roles of synovial fibroblasts will be crucial for the establishment of novel therapeutics that would be complementary to current therapies focused on modulating the inflammatory response.

In this project, you will have the opportunity to learn and apply cutting edge technology such as RNAseq, FACS sorting, multicolor histology and analysis of complex datasets. Moreover, the emerging importance of synovial fibroblast in RA pathogenesis will strategically position you as a new biology leader in the autoimmunity field while also giving you critical industry experience.

ROLE RESPONSIBILITIES

  • Computational analysis of complex datasets
  • Isolate specific cell population by flow cytometry to characterize them in vitro
  • Establish model systems to decipher interactions of synovial fibroblasts with innate immune cell types
  • Validate findings in murine models of arthritis
  • Present findings at internal and external conferences, and publish results in high impact peer-reviewed journals

BASIC QUALIFICATIONS

  • Recent PhD in immunology, bioinformatics or related field (0-4 years)
  • Strong track record of scientific publications
  • Hands-on experience with basic immunological techniques, including cell culture, cell isolation, multi-color flow cytometry, immunohistochemistry
  • Basic programming skills or understanding of systems immunology
  • Ability to work efficiently in a team
  • Excellent oral and written communication skills

PREFERRED QUALIFICATIONS

  • Molecular and computational expertise
  • Hands-on experience in murine model of arthritis

EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Apply
Apply with LinkedIn


Homology Medicines – Director, Discovery Research – Immunology

Location: Bedford, MA

The Director , Discovery Research will work in a project team environment. Internally, she or he will interface directly with multiple functional areas including preclinical research, bioinformatics and molecular genomics, target biology, and vector production. In addition, the successful candidate will be a hands-on scientist, actively driving projects in the laboratory. Externally, she or he will also liaison to external alliance partners, CROs, vendors, academics, and others.

Essential Functions and Duties:

  • Play active hands-on role in investigating the host immune response to our novel AAVHSC vectors (Elispot, neutralizing antibody assays, etc) employing a variety of modern molecular/cell biology techniques
  • Develop and implement in vitro cell culture assays to assess AAVHSC-mediated
  • Manage external project communications in order to provide up-to-date project information and documentation to the team.
  • Company representative for management of programs at external CROs, academic centers, and research partners.

Experience:

  • PhD preferred, training in immunology is essential, background in viral gene therapy and AAV is preferred.
  • Hands on experience in wide variety of molecular techniques including FACS, Elispot, ddPCR, qPCR techniques, tissue culture etc.

Contact:

John Rynak
Senior Staffing Consultant
Homology Medicines
617-645-1345
jrynak@homologymedicines.com