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Plenary Speaker
Diane Mathis, Ph.D.
Regulation of Auto-inflammatory
Responses
Diane Mathis
obtained a B.Sc. from Wake Forest University and a Ph.D. from the
University of Rochester. She performed postdoctoral studies at the
Laboratoire de Génétique Moléculaire des Eucaryotes in Strasbourg,
France and at Stanford University Medical Center. She returned to
France at the end of 1983, establishing a laboratory at the Institut de
Genetique et de Biologie Moleculaire et Cellulaire in Strasbourg, in
conjunction with Dr Christophe Benoist. The lab moved to the Joslin
Diabetes Center at the end of 1999. Dr Mathis is currently a Professor
of Medicine at Brigham and Women’s Hospital and Harvard Medical School,
and is an Associate Research Director and Head of the Section on
Immunology and Immunogenetics at Joslin, where she holds the William T.
Young Chair in Diabetes Research. She is Director of the JDRF Center on
Immunological Tolerance in Type-1 Diabetes at HMS, a Principle Faculty
Member at the Harvard Stem Cell Institute and an Associate Faculty
Member of The Broad Institute. Dr Mathis was elected to the US Academy
of Sciences in 2003 and to the German Academy in 2007.
The lab works in the fields of T cell differentiation and autoimmunity,
with a special emphasis on exploiting the most advanced transgenic and
gene-targeting technology to engineer new mouse models. Studies on
autoimmunity explore the immunological mechanisms of diabetes,
rheumatoid arthritis and APECED, a polyglandular autoimmune disease.
Major questions tackled are what initiates these diseases, how is their
progression regulated, and what are the final effector mechanisms. In
addition, modern genetic and genomic approaches are used to identify
disease-modifying genes in both human patients and mouse models, and
the application of computational and bioinformatic strategies to these
and other issues is explored. Whole-animal imaging of inflammation and
its tissular effects in diabetes and arthritis models is pursued as
part of a long-standing collaborative program.
The Mathis/Benoist laboratory has produced over 250 publications and
trained over 100 students and postdoctoral fellows.
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